Effects of UV Radiation and Oxidative DNA Adduct 8-hydroxy-2’-deoxiguanosine on the Skin Diseases

Excessive sun exposure may be associated with increased oxidative stress and oxidative damage of DNA. Based on this hypothesis, the authors focused on investigating the causal role of UV-induced genomic damage in the pathophysiology of porphyria cutaneatarda (photosensitive acquired metabolic disorder with autosomal dominanttransmittion). In this study we demonstrated that serum levels of 8-hydroxy-2'deoxyguanosine, analteredgene product, was correlated with body iron content(hemoglobin, sideremia, transferrin, ferritin) in patients with porphyria cutanea tarda. Ironis involved in malignant processes by determining oxidative damage of DNA. Reduction of body iron content and genetic manipulation could have positive implications in prevention and progression of diseases mediated by oxidative stress.